Preclinical Neuroscience

 

Better treatments for broken brains.

Dr Martin Engel
Martin Engel

I develop & test novel treatments in experimental models of schizophrenia, Alzheimer’s Disease and brain tumours, connecting the knowledge from the clinic with my work at the lab bench. To conduct relevant research with long-term impact, engage with patients, clinicians and government, to understand the needs and options, share my enthusiasm and communicate my work.

Latest Publications

Paper: Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research

Paper: Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research

Differentiating stem cells into neurons is gaining more and more traction, but is still a very challenging task. We have...

Paper: mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia

We published our preclinical antipsychotic study with my PhD supersivors and fellow PhD students. We show with this work, that the...

Paper: Metabotropic glutamate receptor 5 and its trafficking molecules, Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia

Paper: Metabotropic glutamate receptor 5 and its trafficking molecules, Norbin and Tamalin, are increased in the CA1 hippocampal region of subjects with schizophrenia

Our manuscript on altered mGluR5 expression and signaling in individuals with schizophrenia just got published in Schizophrenia Research: Metabotropic glutamate receptor...

Paper: Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation

Paper: Alterations of mGluR5 and its endogenous regulators Norbin, Tamalin and Preso1 in schizophrenia: towards a model of mGluR5 dysregulation

Our manuscript on altered mGluR5 expression and signaling in individuals with schizophrenia just got published in Acta Neuropathologica: Alterations of mGluR5...

Recent Posts on Neuroscience, Lab work and beyond

Protocols: Maintaining happy iPSC colonies

Episode 1: Let’s start at the beginning, maintaining your iPSC colonies Keeping healthy iPSC colonies, better for clean cultures than...

Protocols: New Tips & Tricks miniseries on maintaining and differentiating iPSCs

Growing stem cells and differentiating them into neuronal cells is difficult work. This miniseries has the tips and tricks I...

Blog: Challenges and solutions for migrating your lab to OneNote

After writing about how to use OneNote as an electronic lab book, we have migrated our lab group from paper...

Blog: Peer Review Checklist

Blog: Peer Review Checklist

We all get asked to review, which can be a laborious task. I made a checklist which helps me and...