Preclinical Neuroscience

 

Strengthening fragile synapses.

Dr Martin Engel
Martin Engel

I develop & test novel treatments in experimental models of schizophrenia, Alzheimer’s Disease and brain tumours, connecting the knowledge from the clinic with my work at the lab bench. To conduct relevant research with long-term impact, engage with patients, clinicians and government, to understand the needs and options, share my enthusiasm and communicate my work.

Latest Publications

Paper: Liraglutide prevents metabolic side-effects and improves recognition and working memory during antipsychotic treatment in rats.

Paper: Liraglutide prevents metabolic side-effects and improves recognition and working memory during antipsychotic treatment in rats.

Some progress in my neuropharmacology portfolio of novel treatment options: we have just published our assessment of Liraglutide to combat...

Paper: Unmasking the true identity in neuron differentiation

Paper: Unmasking the true identity in neuron differentiation

Just weeks after our review on problems with current differentiation protocols, a method for iPSC-derived cholinergic neurons got published in...

Paper: Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research

Paper: Common pitfalls of stem cell differentiation: a guide to improving protocols for neurodegenerative disease models and research

Differentiating stem cells into neurons is gaining more and more traction, but is still a very challenging task. We have...

Paper: mGluR2/3 agonist LY379268 rescues NMDA and GABAA receptor level deficits induced in a two-hit mouse model of schizophrenia

We published our preclinical antipsychotic study with my PhD supersivors and fellow PhD students. We show with this work, that the...

Recent Posts on Neuroscience, Lab work and beyond

Paper: Liraglutide prevents metabolic side-effects and improves recognition and working memory during antipsychotic treatment in rats.

Paper: Liraglutide prevents metabolic side-effects and improves recognition and working memory during antipsychotic treatment in rats.

Some progress in my neuropharmacology portfolio of novel treatment options: we have just published our assessment of Liraglutide to combat...

Protocols: Maintaining happy iPSC colonies

Episode 1: Let’s start at the beginning, maintaining your iPSC colonies Keeping healthy iPSC colonies, better for clean cultures than...

Protocols: New Tips & Tricks miniseries on maintaining and differentiating iPSCs

Growing stem cells and differentiating them into neuronal cells is difficult work. This miniseries has the tips and tricks I...

Blog: Challenges and solutions for migrating your lab to OneNote

After writing about how to use OneNote as an electronic lab book, we have migrated our lab group from paper...