Blog: 366 papers in 2016
Starting 2016 with a stronger public science engagement, I decided to publish my 2016 science readings together with Natalie Matosin (Twitter), Rhiannon Morris (Twitter) and Lauren Drogos (Twitter).
Enjoy the glimpse of what I’m currently interested in! You can easily follow this list on twitter via the #366papers tag or my account.
Looking forward to a journey through stem cells, Alzheimer’s Disease, Glioblastoma, Neuregulin 1 and much more!
January-March 2016 papers:
- Verhaak, R.G.W. et al., 2010. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer cell, 17(1), pp.98–110.
- Promising translation of glioblastoma treatment from in vitro to in vivo
Singh, M.M., et al., 2015. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro-oncology 17, 1463–1473. doi:10.1093/neuonc/nov041 - glioblastoma stem cells resist cell-cycle exit treatment and continue proliferation
Carén, H., et al., 2015. Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest. Stem Cell Reports. doi:10.1016/j.stemcr.2015.09.014 - in vitro glioblastoma study shows depletion of glutathione triggers cancer cell death
Khan, M., et al., 2012. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life 64, 783–794. doi:10.1002/iub.1068 - Wide spread problem preclinical neuroscience false positives, overestimated effect size
Holman, C., et al., 2016. Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke. PLOS Biology 14, e1002331. doi:10.1371/journal.pbio.1002331 - Regulators of H3 methylation & acetylation for neuronal activity-dependent gene expression
Malik, A.N., et al., 2014. Genome-wide identification and characterization of functional neuronal activity-dependent enhancers. Nat. Neurosci. 17, 1330–1339. doi:10.1038/nn.3808 - Trigger oxidative stress in cancer cells selectively kills them. Promising invivo & invitro work
Noh, J., et al., 2015. Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death. Nat Commun 6, 6907. doi:10.1038/ncomms7907 - Necessary reminder of reporting standards to ensure quality of common methods, such as westernblots
Gilda, J.E. et al., 2015. Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). PLOS ONE, 10(8), p.e0135392. - Direct conversion fibroblasts to neurons better than iPSC to retain age profile?
Mertens, J., et al., 2015. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell 17, 705–718. doi:10.1016/j.stem.2015.09.001 - Promising development for maternal RSV immunization, only concern is maternal infection and schizophrenia risk
Mullard, A., 2016. Making way for maternal immunization. Nature Reviews Drug Discovery 15, 3–4. doi:10.1038/nrd.2015.38 - Excellent work showing why amyloid-B clearing antibodies don’t reduce neurodegeneration in Alzheimer’s Disease
Yuan, P. & Grutzendler, J., 2016. Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer’s models. Nature Neuroscience 18, 1725–1727, doi:10.1038/nn.4163 - Less neuron activity lowers AB deposition but what are behavior consequences?
Busche, MA., et al., 2015. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. The Journal of Neuroscience, 36(2), pp.632–641, doi: 10.1523/JNEUROSCI.2531-15.2016 - Excellent (slightly dated) review on the fascinating hippocampus network structure
Klausberger, T. & Somogyi, P., 2008. Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science (New York, N.Y.), 321(5885), pp.53–57, doi: 10.1126/science.1149381 - Interesting use of flowcytometry for synapse Amyloid & tau levels in Alzheimer’s pathology
Bilousova, T., et al., 2016. Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. The American Journal of Pathology 186, 185–198. doi:10.1016/j.ajpath.2015.09.018
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Neurons in a dish develop “small world” hubs. Fascinating work on network development
Downes, J.H., et al., 2012. Emergence of a Small-World Functional Network in Cultured Neurons. PLoS Comput Biol 8, e1002522. doi:10.1371/journal.pcbi.1002522 -
Excellent review about the use of iPSC-derived motor neurons to study ALS
Sances et al. 2016. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nature Neuroscience 16, 542–553 (2016) doi:10.1038/nn.4273 -
Elegant experiment showing that four schizophrenia-related synapse proteins (DISC1, Disruped in schizophrenia 1; NRG1, neuregulin 1, ERBB4, PSD95) interact to control GABAergic synapse numbers.
Seshadri, S., et al., 2015. Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex. Nat Commun 6, 10118. doi:10.1038/ncomms10118 -
Interesting commentary on the mechanisms which allow HIV to escape CRISPR-based treatment strategies.
Ewen Callaway, 2016. HIV overcomes CRISPR gene-editing attack. Nature 08.04.2016.