Blog: 366 papers in 2016

Starting 2016 with a stronger public science engagement, I decided to publish my 2016 science readings together with Natalie Matosin (Twitter), Rhiannon Morris (Twitter) and Lauren Drogos (Twitter).

Enjoy the glimpse of what I’m currently interested in! You can easily follow this list on twitter via the #366papers tag or my account.

Looking forward to a journey through stem cells, Alzheimer’s Disease, Glioblastoma, Neuregulin 1 and much more!

January-March 2016 papers:

  1. Verhaak, R.G.W. et al., 2010. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1. Cancer cell, 17(1), pp.98–110.
  2. Promising translation of glioblastoma treatment from in vitro to in vivo
    Singh, M.M., et al., 2015. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro-oncology 17, 1463–1473. doi:10.1093/neuonc/nov041
  3. glioblastoma stem cells resist cell-cycle exit treatment and continue proliferation
    Carén, H., et al., 2015. Glioblastoma Stem Cells Respond to Differentiation Cues but Fail to Undergo Commitment and Terminal Cell-Cycle Arrest. Stem Cell Reports. doi:10.1016/j.stemcr.2015.09.014
  4. in vitro glioblastoma study shows depletion of glutathione triggers cancer cell death
    Khan, M., et al., 2012. Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life 64, 783–794. doi:10.1002/iub.1068
  5. Wide spread problem preclinical neuroscience false positives, overestimated effect size
    Holman, C., et al., 2016. Where Have All the Rodents Gone? The Effects of Attrition in Experimental Research on Cancer and Stroke. PLOS Biology 14, e1002331. doi:10.1371/journal.pbio.1002331
  6. Regulators of H3 methylation & acetylation for neuronal activity-dependent gene expression
    Malik, A.N., et al., 2014. Genome-wide identification and characterization of functional neuronal activity-dependent enhancers. Nat. Neurosci. 17, 1330–1339. doi:10.1038/nn.3808
  7. Trigger oxidative stress in cancer cells selectively kills them. Promising invivo & invitro work
    Noh, J., et al., 2015. Amplification of oxidative stress by a dual stimuli-responsive hybrid drug enhances cancer cell death. Nat Commun 6, 6907. doi:10.1038/ncomms7907
  8. Necessary reminder of reporting standards to ensure quality of common methods, such as westernblots
    Gilda, J.E. et al., 2015. Western Blotting Inaccuracies with Unverified Antibodies: Need for a Western Blotting Minimal Reporting Standard (WBMRS). PLOS ONE, 10(8), p.e0135392.
  9. Direct conversion fibroblasts to neurons better than iPSC to retain age profile?
    Mertens, J., et al., 2015. Directly Reprogrammed Human Neurons Retain Aging-Associated Transcriptomic Signatures and Reveal Age-Related Nucleocytoplasmic Defects. Cell Stem Cell 17, 705–718. doi:10.1016/j.stem.2015.09.001
  10. Promising development for maternal RSV immunization, only concern is maternal infection and schizophrenia risk
    Mullard, A., 2016. Making way for maternal immunization. Nature Reviews Drug Discovery 15, 3–4. doi:10.1038/nrd.2015.38
  11. Excellent work showing why amyloid-B clearing antibodies don’t reduce neurodegeneration in Alzheimer’s Disease
    Yuan, P. & Grutzendler, J., 2016. Decreased amyloid-β and increased neuronal hyperactivity by immunotherapy in Alzheimer’s models. Nature Neuroscience 18, 1725–1727, doi:10.1038/nn.4163
  12. Less neuron activity lowers AB deposition but what are behavior consequences?
    Busche, MA., et al., 2015. Attenuation of β-Amyloid Deposition and Neurotoxicity by Chemogenetic Modulation of Neural Activity. The Journal of Neuroscience, 36(2), pp.632–641, doi: 10.1523/JNEUROSCI.2531-15.2016
  13. Excellent (slightly dated) review on the fascinating hippocampus network structure
    Klausberger, T. & Somogyi, P., 2008. Neuronal diversity and temporal dynamics: the unity of hippocampal circuit operations. Science (New York, N.Y.), 321(5885), pp.53–57, doi: 10.1126/science.1149381
  14. Interesting use of flowcytometry for synapse Amyloid & tau levels in Alzheimer’s pathology
    Bilousova, T., et al., 2016. Synaptic Amyloid-β Oligomers Precede p-Tau and Differentiate High Pathology Control Cases. The American Journal of Pathology 186, 185–198. doi:10.1016/j.ajpath.2015.09.018
  15. Neurons in a dish develop “small world” hubs. Fascinating work on network development
    Downes, J.H., et al., 2012. Emergence of a Small-World Functional Network in Cultured Neurons. PLoS Comput Biol 8, e1002522. doi:10.1371/journal.pcbi.1002522
  16. Excellent review about the use of iPSC-derived motor neurons to study ALS
    Sances et al. 2016. Modeling ALS with motor neurons derived from human induced pluripotent stem cells. Nature Neuroscience 16, 542–553 (2016) doi:10.1038/nn.4273
  17. Elegant experiment showing that four schizophrenia-related synapse proteins (DISC1, Disruped in schizophrenia 1; NRG1, neuregulin 1, ERBB4, PSD95) interact to control GABAergic synapse numbers.
    Seshadri, S., et al., 2015. Interneuronal DISC1 regulates NRG1-ErbB4 signalling and excitatory-inhibitory synapse formation in the mature cortex. Nat Commun 6, 10118. doi:10.1038/ncomms10118
  18. Interesting commentary on the mechanisms which allow HIV to escape CRISPR-based treatment strategies.
    Ewen Callaway, 2016. HIV overcomes CRISPR gene-editing attack. Nature 08.04.2016.
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